The Confusing State of Sepsis Definition SUMMARY There is large variability in incidence and clinical outcome (including mortality) in sepsis patients based on the definition used. The differing definitions make it difficult for providers and health systems to: Evaluate

Low Agreement in Sepsis Time-Zero Determination SUMMARY Variability in time-zero determination may limit the interpretation of pass/fail sepsis bundle compliance. Three different definitions exist to meet time-zero criteria. There is wide variability between clinicians and abstractors in determining time-zero

4 Ways COVID-19 is Similar to Sepsis SUMMARY A number of common features are shared by severe coronavirus disease (COVID-19) and sepsis. Organ dysfunction caused by COVID-19 can be depicted as viral sepsis As a syndrome, both COVID-19 and

The Health Burden of Sepsis After Hospitalization SUMMARY A number of health complications are known to develop after an episode of sepsis referred to as the "Post-Sepsis Syndrome" There is inconclusive data if the syndrome is attributable to the

Septic Shock: The Balance Between Fluid and Vasopressor Administration on Mortality SUMMARY Increasing doses of vasopressors within the first 6 hours are associated with increased mortality unless paired with at least 2,000 mL of fluid administration. Increasing vasopressor doses

Efforts to Improve Sepsis Outcomes Before Hospitalization SUMMARY Most sepsis cases begin outside the hospital with a diverse range of clinical findings. Evaluation of sepsis patients should include administrative claims data coupled with physiologic and laboratory data. Characterization of