Carbapenem Resistant Gram Negative Bacilli SUMMARY The continued growth of multidrug resistant organisms, particularly carbapenem resistant Gram negative rods, places a heavy burden on the healthcare system globally Effective treatment regimens remain a challenge. Although combination therapy is typically used, robust evidence to support this strategy is lacking. There are
Sepsis Associated Acute Kidney Injury: Knowns and Unknowns SUMMARY By the time patients seek attention, most have already developed acute kidney injury. Sepsis associated acute kidney injury is a distinct syndrome different from other non-sepsis acute kidney injuries. There is a lack of specific interventions for the prevention and treatment of
Will Improving CMS SEP-1 Metrics Correlatewith Sepsis Clinical Outcomes? SUMMARY CMS SEP-1 quality metrics can consume large amounts of hospital resources in order to collect and report their adherence. Hospitals solely focusing on the SEP-1 reporting should not assume this will automatically correlate with improved clinical outcomes of sepsis patients. A
Components of Timely Antibiotic Administration in Sepsis SUMMARY There are at least 2 components to consider in timely antibiotic use in sepsis patients. The time from triage to ordering antibiotics caused four-fifths of the delay in meeting the 3-hour bundle goal. Both recognition and administration delays were associated with hospital mortality
The Confusing State of Sepsis Definition SUMMARY There is large variability in incidence and clinical outcome (including mortality) in sepsis patients based on the definition used. The differing definitions make it difficult for providers and health systems to: Evaluate outcomes such as Time-Zero, mortality and length of stay Implement quality improvement initiatives Compare results between
Low Agreement in Sepsis Time-Zero DeterminationSUMMARYVariability in time-zero determination may limit the interpretation of pass/fail sepsis bundle compliance.Three different definitions exist to meet time-zero criteria.There is wide variability between clinicians and abstractors in determining time-zero with poor interrater reliability. BACKGROUND Sepsis bundle compliance is a timed measure relative to the first point
4 Ways COVID-19 is Similar to Sepsis SUMMARY A number of common features are shared by severe coronavirus disease (COVID-19) and sepsis. Organ dysfunction caused by COVID-19 can be depicted as viral sepsis As a syndrome, both COVID-19 and sepsis present with a heterogeneous physiologic and alterations in biochemical values. BACKGROUND Sepsis
The Health Burden of Sepsis After Hospitalization SUMMARY A number of health complications are known to develop after an episode of sepsis referred to as the "Post-Sepsis Syndrome" There is inconclusive data if the syndrome is attributable to the sepsis episode or pre-existing co-morbidities. Increased risk of mortality, readmission, length of stay, cost of
Septic Shock: The Balance Between Fluid and Vasopressor Administration on Mortality SUMMARY Increasing doses of vasopressors within the first 6 hours are associated with increased mortality unless paired with at least 2,000 mL of fluid administration.Increasing vasopressor doses are associated with increasing mortality over the first 24 hours of septic shock.Additional evaluations optimal balance between
Efforts to Improve Sepsis Outcomes Before Hospitalization SUMMARYMost sepsis cases begin outside the hospital with a diverse range of clinical findings.Evaluation of sepsis patients should include administrative claims data coupled with physiologic and laboratory data.Characterization of sepsis prior to hospitalization can highlight key areas for education and preemptive care to improve identification, interventions and monitoring
