A recent review of 616 patients with septic shock from 33 hospitals retrospectively evaluated vasopressor administration following fluid resuscitation.
- Data from September 1, 2017 – February 1, 2018, consecutive septic shock patients
- The goals were to:
o Determine if vasopressor response varies depending on fluid administration volume.
o Determine the association between vasopressor dosing and 30-day in-hospital mortality.
- Data from 12 hours before to 24 hours following shock onset.
- Fluid administration was the total volume of all fluids and blood products administered from 0-24 hours.
o Dopamine; epinephrine; norepinephrine; phenylephrine; vasopressin
o All doses converted to “Norepinephrine Equivalents” (NEE).
o NEE determined for 0-6 hours and 0-24 hours with time-weighted rules.
- Vasopressor Dosing Intensity (VDI) across the 2 time periods were categorized as: