A number of common features are shared by severe coronavirus disease (COVID-19) and sepsis.
Organ dysfunction caused by COVID-19 can be depicted as viral sepsis
As a syndrome, both COVID-19 and sepsis present with a heterogeneous physiologic and alterations in biochemical values.
Sepsis is not a discrete entity, rather it is a syndrome consisting of a constellation of signs, symptoms and laboratory findings. This is described by the most recent definition of sepsis as a dysregulated host inflammatory response related to infection along with new onset organ dysfunction.
Although there have been improved trends in prognosis for sepsis patients over the past several decades, generating reproducible results in sepsis trials is been challenging.
Potential reasons for the lack of consistency are:
the heterogeneity of the patient population
various baseline standard care provided
lack of precision in better segmentation of the heterogeneity of sepsis
COVID-19 has affected almost every country in the world. As we gain a better understanding of this infection, it has become clear the initial viral replication of the SAR-CoV-2 virus in severe cases is followed by an inadequate host response.
In its worse form, COVID-19 results in acute respiratory distress syndrome along with dysfunction of other organs.
Multi-organ failure is present in most deaths.
COVID-19 cases have a heterogeneity within the patient population
With the high complexity and heterogeneity of both disease states, there seems to be commonalities worth highlighting.
Patients with both COVID-19 and sepsis consist of very heterogeneous groups of patients, with multiple characteristics.
Various classes of agents have been suggested to combat COVID-19 and sepsis.
Better characterization of patients is needed to help provide a more personalized patient as well as treatment selection approach with both COVID-19 and sepsis.