Should Hemodynamic Profiling be a Sepsis Best Practice? SUMMARY Hemodynamic profiles in critically ill patients are complex and change over the sepsis course. Macro-circulatory and micro-circulatory factors contribute equally to the evolving disease state. During the later stages of hemodynamic impairment, both factors must be considered. BACKGROUNDIn addition to
Sepsis Associated Encephalopathy (SAE) SUMMARYSAE is a key manifestation of sepsis occurring in up to 70% of ICU patientsAssociated with higher ICU and hospital mortality and long term consequencesDifficult to assess, diagnose without specific treatment BACKGROUNDSAE is probably the most common type of encephalopathy in the ICUSAE may occur
Top 10 Key Perspectives for Sepsis in 2022 SUMMARY The challenge of sepsis remains for most clinicians There is no one-size fits all approach Several unresolved key areas will remain with us into the next year TOP 10 SEPSIS KEY PERSPECTIVES (in no particular order)
Is the Mortality Rate from Sepsis Improving? SUMMARY The true incidence of sepsis is difficult to define. Sepsis cases are not evenly distributed Despite global efforts on improved recognition and management, the overall sepsis mortality rate has been stable. Sub-segments of the population may be experiencing increasing mortality rates. BACKGROUND
How Should We Screen for Sepsis? SUMMARY Organ dysfunction is one of the defining characteristics in the current definition of sepsis. Many of the markers currently in use are nonspecific. Organ dysfunction and injury are separate processes that need to be differentiated. Understanding ways dysfunction can be better detected will
How Should We Screen for Sepsis? SUMMARY Sepsis screening remains a major challenge, especially in varied settings. Effective screening impacts treatment, quality of care initiatives and outcomes. Different screening tools may be needed based on the clinical setting. The tool at each site may need to be tuned uniquely for that population
Optimal Modes of Sepsis Care Delivery SUMMARY The 2016 Surviving Sepsis Campaign guidelines (Sepsis-3) provided a new definition for sepsis, but also raised new questions. Recently the Sepsis-3 Research Committee listed priorities for further consideration. The only area focusing on sepsis administrative issues was on the optimal mode of care delivery. REVIEW
5 Tips with Electronic Sepsis Notification Systems Numerous studies have developed electronic tools for the detection of sepsis. As machine learning evolves, many more will probably abound. Most evaluations are fraught with methodologic design pitfalls which preclude widespread implementation and use for patient identification and improved clinical outcomes. The following
Carbapenem Resistant Gram Negative Bacilli SUMMARY The continued growth of multidrug resistant organisms, particularly carbapenem resistant Gram negative rods, places a heavy burden on the healthcare system globally Effective treatment regimens remain a challenge. Although combination therapy is typically used, robust evidence to support this strategy is lacking. There are
Sepsis Associated Acute Kidney Injury: Knowns and Unknowns SUMMARY By the time patients seek attention, most have already developed acute kidney injury. Sepsis associated acute kidney injury is a distinct syndrome different from other non-sepsis acute kidney injuries. There is a lack of specific interventions for the prevention and treatment
