Triglyceride-Glucose Index in Sepsis
SUMMARY:
-
Sepsis induces extensive release of inflammatory factors and stresses producing various imbalances.
-
Insulin resistance diminishes peripheral tissue insulin sensitivity.
-
The Triglyceride-Glucose Index (TyGI) has been presented as a surrogate marker of insulin resistance.
-
TyGI has been associated with various diseases and is emerging as a possible indicator in sepsis.
REVIEW:
- The overall relationship between blood glucose and glycemic variability remains unclear.
-
Infection and inflammation also cause dramatic changes in lipid and lipoprotein levels within sepsis patients.
-
High plasma triglyceride concentrations have been associated with higher mortality rates in sepsis patients.
-
- Triglyceride Levels (max): Survivors = 148.0; Non-Survivors = 136.0 (p0.013)
-
-
TyGI Calculation: Natural Log (Initial Triglyceride x Initial Plasma Glucose)/2
- TyGI correlated with: contrast induced nephropathy; risk of ischemic stroke; coronary artery disease.
- Relationship of TyGI in sepsis is only now being elucidated.
- TyGI is independently being associated with increased sepsis mortality.


-
Acute Kidney Injury in Sepsis
- 45 – 70% of acute kidney injuries (AKI) are secondary to sepsis
-
- Sepsis AKI is linked to: poorer prognosis; longer length of stay; cardiovascular events; mortality.
-
- A review of 1,426 patients with sepsis indicates TyGI is correlated with sepsis associated AKI and prolonged LOS.

CONCLUSIONS:
-
Initial studies demonstrate TyGI has a significant association between increased values and mortality and incidence of sepsis AKI.
-
It remains unclear if the TyGI can be used for the prognosis or provide insights contributing to the clinical management and monitoring of sepsis patients.
-
Additional investigation in this area is warranted.
To receive articles like these in your Inbox, you can subscribe to Sepsis Program Optimization Insights.
Erkan Hassan is the Co-Founder & Chief Clinical Officer of Sepsis Program Optimization where he designs & oversees the implementation of solutions to optimize sepsis programs.
To discuss your organization’s Barriers of Effective Sepsis Care, contact Erkan by phone (844) 4SEPSIS (844-473-7747), email (erkan@spo.icu), or video chat.