The Changing Definition of Sepsis in Clinical Practice SUMMARY There is no gold standard to the definition of sepsis International conferences have evolved the definition of sepsis since 1991 by combining non-specific physiologic and

4 Barriers to Effective Sepsis CareSUMMARY1.7 million adult sepsis cases in U.S. annually270,000 deaths annually with an overall mortality rate of 27-36%Despite recent advances there remains ongoing discussions regarding the best definitions, methods of screening