Sepsis Clinical Probability Determination and Antibiotic Timing SUMMARY Accurate diagnosis of sepsis upon presentation is challenging due to subtle disease presentation or rapidly progressing symptoms. Early administration of antibiotics is one of the most effective interventions, especially with severe disease, however, must be balanced with the risk of potential harm. Surviving Sepsis
The Use of Artificial Intelligence in Sepsis SUMMARYIncorporating artificial intelligence into sepsis is a complex and challenging issue.Artificial intelligence algorithms in sepsis may be applied to: prediction; prognosis; mortality prediction; and optimal management.Limited data suggests artificial intelligence may provide a new approach to sepsis, but optimal provider input and considerations remain elusive.REVIEWArtificial
The 4 Phases of Fluid Therapy in Sepsis SUMMARYFluid therapy is an important component of sepsis therapy and may be administered during any phase of sepsis illness.While hemodynamic benefits may occur during initial fluid therapy, excessive amounts can be deleterious.Timing, rate and volume of fluid administration and removal vary based on the
Sepsis Now Part of CMS Value-Based Purchasing Program SUMMARY The U.S. Center for Medicare and Medicaid Services (CMS) Severe Sepsis and Septic Shock Early Management Bundle (SEP-1) lays out the process for providers to follow in the care of the sepsis patient. First published in 2015, then amended in 2018, CMS is
Machine Learning Predictive Spesis Models SUMMARYVarious machine learning sepsis prediction models exist and are promoted to facilitate early identification of patients at high risk for sepsis.Most are based on electronic health record data.Results range from producing improvements in outcomes to poor discrimination and calibration with poor predictability of sepsis onset and no
The Neurologic Complications of Sepsis SUMMARY Nervous system manifestations are often the first sign of organ failure to occur in sepsis. There are a wide range of clinical syndromes including confusion, seizures, and cerebrovascular events. The 2 most common are Sepsis associated encephalopathy and ICU acquired weakness. Current diagnostic and management strategies
Early Restrictive or Liberal Fluid Management for Sepsis: The CLOVERS Study SUMMARY Complete fluid resuscitation should consider macrovascular perfusion as well as microvascular perfusion. There is a lack of data to adequately guide clinicians on fluid and vasopressor use in early sepsis. The CLOVERS study suggests restrictive fluid with early
Rethinking IV Fluid Resuscitation in Sepsis SUMMARY Fluid resuscitation is a key component in the management of sepsis and shock to improve fluid volume. The risks of fluid overload may contribute to poorer outcomes. Despite widespread support for fluid resuscitation, data supporting large volumes is limited. REVIEW The Surviving Sepsis Campaign recommends
Sepsis Performance Programs Can Optimize Patient Outcomes SUMMARY Sepsis performance improvement programs can optimize compliance with sepsis protocols and are associated with improved patient outcomes. Having a Sepsis Performance Improvement program is more important than the specific content of the program. Engaging a large multidisciplinary group of clinical leaders is
Sepsis Mortality Based on Origin of Source SUMMARY Sepsis sources of infection come from a variety of origins. Source control is a major determinant affecting outcomes in patients with sepsis. The source of the sepsis origin may partially contribute to varying mortality rates. Infection source should be considered in sepsis
