A set of foundational articles about sepsis.
Evolution and Current Status of Sepsis Bundles SUMMARY The Sepsis Bundles have been a key component to the implementation of the Surviving Sepsis Guidelines. The 2 different original resuscitation and management bundles have evolved over time both in terms of timeframe for completion and elements. There is unresolved controversy surrounding the newest 1-hour bundle
The Changing Definition of Sepsis in Clinical Practice SUMMARY There is no gold standard to the definition of sepsis International conferences have evolved the definition of sepsis since 1991 by combining non-specific physiologic and laboratory abnormalities. These conferences as well as the Centers for Medicare and Medicaid Services (CMS) offer clinicians various sepsis definitions.
4 Barriers to Effective Sepsis CareSUMMARY1.7 million adult sepsis cases in U.S. annually270,000 deaths annually with an overall mortality rate of 27-36%Despite recent advances there remains ongoing discussions regarding the best definitions, methods of screening and appropriate treatment selection or amounts to administerThese remain common barriers to successful sepsis care programsBACKGROUNDOver the past several decades,
