Sepsis Mortality Based on Origin of Source

  • Sepsis sources of infection come from a variety of origins.
  • Source control is a major determinant affecting outcomes in patients with sepsis.
  • The source of the sepsis origin may partially contribute to varying mortality rates.
  • Infection source should be considered in sepsis program development.
  • Due to the heterogeneous nature of sepsis, a variety of sources may be the origin of the infection.
  • Consistently, the most common source origin is the pulmonary system. However, clinicians also need to consider a number of other sites.
  • Recently Prest et al evaluated sepsis patients stratified by the 3 most common sites of infection in over 2.5 million sepsis cases reported through the CDC.
    • Pulmonary
    • Intraabdominal
    • Genitourinary tract
  • Pulmonary sepsis patients had the highest mortality rate, followed by GU sepsis, then Intrabdominal sepsis.
  • Males had a significantly higher mortality rate (approximately 26% higher age-adjusted) than females within each source origin.
  • Sepsis mortality increase not only by organ system affected, but by increasing age as well.
  • Pulmonary remained the leading cause of death by age group as well.
  • The site of infection origin is important ot consider in the effort to combat sepsis.
  • The organ affected as well as the patients age should be factors to consider in developing sepsis processes and policies.

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Erkan Hassan is the Co-Founder & Chief Clinical Officer of Sepsis Program Optimization where he designs & oversees the implementation of solutions to optimize sepsis programs.

To discuss your organization’s Barriers of Effective Sepsis Care, contact Erkan by phone (844) 4SEPSIS (844-473-7747), email (, or video chat.