i. Simple to remember tools (i.e. SIRS) do not account for organ dysfunction.
ii. Evidence demonstrating accuracy is limited.
iii. Dependent of absolute cut-points.
iv. Not tuned to local conditions.
v. Must balance excessive notifications with delays in assessments.
vi. Limited availability of data.
vii. Non-specific for sepsis.
Areas For Future Improvement
- Best screening tool for each setting has not been established.
- Sepsis screening needs to be aligned with work flow changes and outcomes.
- Screening should initially focus on suspected infection.
- Identification of a dysregulated host response to infection with clinical markers is lacking.
- Improved markers for identification and validation of acute organ dysfunction are needed.