Can Progression from Sepsis to Septic Shock be Predicted?
Approximately 10% of patients with sepsis will progress to septic shock.
Septic Shock is associated with a high mortality rate of approximately 38%.
Limited data exists determining which patients are at risk of progressing from sepsis to septic shock.
A multi-centered large cohort of patients, identify the important determinants to detect septic shock progression.
Approximately 10% of patients with sepsis triaged in the emergency department (ED) will progress to septic shock.
Limited data exists on determining which patients are at risk to progress from sepsis to septic shock.
These studies suffer from:
Small numbers of patients
Single site investigations
Patients with septic shock require a greater amount of resources, have longer length of stays , have higher mortality rates and are costlier per case.
Earlier identification of patients at risk for progression from sepsis to septic shock may aid in appropriate triage, monitoring, interventions and resource allocation, resulting in improved clinical and financial outcomes.
Wardi et al. medRxiv preprint doi: https://doi.org/10.1101/2020.11.02.20224931
Retrospective multi-centered cohort of patients presenting to ED between 2014-2019.
Patients were included if they developed septic shock between 4 hours after ED triage and up to 48 hours after diagnosis of sepsis.
Hourly data of the 40 most commonly measured input variables were developed into a machine learning predictive algorithm,