Source Control in the Management of Sepsis

  • Source control is a major determinant affecting outcomes in patients with sepsis.
  • The need for source control should be linked into the diagnostic process of sepsis patients.
  • Source control should be considered in every sepsis patient, but it may not be necessary to control a source of infection in all patients.
  • Difficulties obtaining source control in sepsis patients include:
    • It’s definition
    • The optimal timing of source control
    • The lack of standardized methods for source control
    • Avoidance or delay of source control is associated with poor outcomes.
  • Source control strategies include:
  • Source Control Sites:
    • Abdominal infections
    • Blood Stream Infections
    • Central Venous Catheter
  • Patient Factors – numerous factors play a role
    • Severity of illness (hemodynamics, respiratory, metabolic)
    • Coagulation
    • Location & extent of infection
    • Ongoing contamination
    • Risk of collateral damage
  • Avoid additional damagery strategy ma
      • In some situations, a temporary be preferred
      • Definitive interventions should occur when patient’s physiologic condition has improved.
  • A failed attempt at source control
    • Ongoing infection
    • Incomplete source control
    • Ongoing contamination
    • Combination of items
  • Appropriate source control is a key factor in sepsis management.
  • Without adequate source control, clinical stabilization or improvement may not occur.

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Erkan Hassan is the Co-Founder & Chief Clinical Officer of Sepsis Program Optimization where he designs & oversees the implementation of solutions to optimize sepsis programs.

To discuss your organization’s Barriers of Effective Sepsis Care, contact Erkan by phone (844) 4SEPSIS (844-473-7747), email (, or video chat.