Myocardial Injury in Sepsis
SUMMARY:
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Sepsis induced myocardial QT prolongation is a serious complication.
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Sepsis is an independent predictor for the development of prolonged QT interval.
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New onset QT interval in sepsis had higher arrhythmias and 30 day mortality.
REVIEW:
Liu et al Critical Care 2024;28:115 doi.org/10.1186/s13054-024-
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Retrospective review of sepsis patients from 2018 – 2022 with sepsis-3 definition.
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1,024 patients (3.3% from ICU).
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QT Prolongation (QTP occurred in 235 (22.9%) of patients.
- QTP Risk Factors
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- Coronary Artery Disease
- Septic Shock
- Acute Heart Failure
- Acute Kidney Injury
- Acute Respiratory Failure
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QTP was statistically related to:
- Clinical Characteristics
- Higher Age
- Lower Body Surface Area
- Hypertension
- Coronary Artery Disease
- Structural Heart Disease
- Renal Insufficiency
- Chronic Obstructive Pulmonary Disease
- Clinical Characteristics
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Myocardial Characteristics
- Higher Sinus Heart Rate
- Wider QRS Width
- Clinical Outcomes
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- Higher 30-day mortality
CONCLUSIONS:
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Occurrence of QTP in sepsis patients is 22.9%.
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Development of QTP in patients with sepsis is an independent predictor of 30 day mortality.
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Patients with sepsis and QTP had an increased incidence of atrial and ventricular arrhythmias during hospitalization.
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Erkan Hassan is the Co-Founder & Chief Clinical Officer of Sepsis Program Optimization where he designs & oversees the implementation of solutions to optimize sepsis programs.
To discuss your organization’s Barriers of Effective Sepsis Care, contact Erkan by phone (844) 4SEPSIS (844-473-7747), email (erkan@spo.icu), or video chat.