How These Findings Should Be Used for Machine Learning Predictive Sepsis Models
1. Using EHR Data is Challenging:
a. Heterogenous data within EHR’s make it difficult to create a single model for clinicians to use.
b. Sepsis is a clinical diagnosis
c. Mean hours from presentation to clinical diagnosis ranged from 2.3 to 8.3 above.
2. One Size Does Not Fit All
a. Customization of workflow within a setting is essential.
b. Development of these workflows should ask: How, When, Which threshold values to be used.
c. This requires close collaboration with staff and bedside clinicians
3. Improved Patient Stratification
a. Based on the November 2021 Surviving Sepsis Campaign Guidelines:
i. High Probability of sepsis patients should receive antibiotics within 1 hour
ii. Moderate probability of sepsis patients should receive antibiotics within 3 hours, after a thorough search for other etiologies
iii. Low probability of sepsis warrants assessment for non-infectious causes of systemic inflammation.