Diagnostic Challenges in Sepsis


  • There remains no single tool to reliably identify sepsis.
  • A variety of approaches exist as well as on the horizon in order to identify infection and sepsis.
  • Identification must bridge the identification of infection with clinical assessment of the sepsis syndrome.


  • Common biochemical markers and microbiological data are typically used to evaluate sepsis patients.
  • While prompt identification and treatment is essential to improve outcomes, there is no “Gold Standard” available to identify these patients.
  • Global collaborative efforts have provided guidelines in definitions and management approaches providing advancements.
  • However, the lack of a reliable tool contributes to the high usage patterns of antibiotics.



  • Applicability is subject to debate
  • Every patient should be screened Every Day, Every Shift
  • There are 2 ways to accomplish this:

COMMON LAB BIOMARKERS – value is debatable




  • Identification and treatment of sepsis must be based on thorough patient assessment and clinical judgement.
  • Novel approaches will aid in this element of optimizing patient care
  • Combining these models with patient data, comorbidities, biomarkers and gene markers seems the appropriate way forward at the present time.

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Erkan Hassan is the Co-Founder & Chief Clinical Officer of Sepsis Program Optimization where he designs & oversees the implementation of solutions to optimize sepsis programs.

To discuss your organization’s Barriers of Effective Sepsis Care, contact Erkan by phone (844) 4SEPSIS (844-473-7747), email (erkan@spo.icu), or video chat.